KETAMINE FACT SHEET FUNDAMENTALS EXPLAINED

Metabolism Ketamine is metabolized by way of N-dealkylation into the active metabolite norketamine mostly by CYP2B6 and CYP3A4 and also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation in the cyclohexone ring to sort hydroxynorketamine compounds by way of CYP-dependent pathways, which are conjugated with glucuronic acid